Tag Archives: mindfulness

Study shows gene expression changes with meditation

18 Thursday Mar 2021

Posted by in Health, Meditation, mental health, mindfulness, Relaxation, research, Wellness

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1378006_10151699852947169_1244682694_nWith evidence growing that meditation can have beneficial health effects, scientists have sought to understand how these practices physically affect the body.

A new study by researchers in Wisconsin, Spain, and France reports the first evidence of specific molecular changes in the body following a period of mindfulness meditation. The study investigated the effects of a day of intensive mindfulness practice in a group of experienced meditators, compared to a group of untrained control subjects who engaged in quiet non-meditative activities. After eight hours of mindfulness practice, the meditators showed a range of genetic and molecular differences, including altered levels of gene-regulating machinery and reduced levels of pro-inflammatory genes, which in turn correlated with faster physical recovery from a stressful situation.

“To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice,” says study author Richard J. Davidson, founder of the Center for Investigating Healthy Minds and the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin-Madison.

“Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs,” says Perla Kaliman, first author of the article and a researcher at the Institute of Biomedical Research of Barcelona, Spain (IIBB-CSIC-IDIBAPS), where the molecular analyses were conducted.

The study was published in the journal Psychoneuroendocrinology.

Mindfulness-based trainings have shown beneficial effects on inflammatory disorders in prior clinical studies. The new results provide a possible biological mechanism for therapeutic effects.

The results show a down-regulation of genes that have been implicated in inflammation. The affected genes include the pro-inflammatory genes RIPK2 and COX2 as well as several histone deacetylase (HDAC) genes, which regulate the activity of other genes epigenetically by removing a type of chemical tag. What’s more, the extent to which some of those genes were downregulated was associated with faster cortisol recovery to a social stress test involving an impromptu speech and tasks requiring mental calculations performed in front of an audience and video camera.

Perhaps surprisingly, the researchers say, there was no difference in the tested genes between the two groups of people at the start of the study. The observed effects were seen only in the meditators following mindfulness practice. In addition, several other DNA-modifying genes showed no differences between groups, suggesting that the mindfulness practice specifically affected certain regulatory pathways.

However, it is important to note that the study was not designed to distinguish any effects of long-term meditation training from those of a single day of practice. Instead, the key result is that meditators experienced genetic changes following mindfulness practice that were not seen in the non-meditating group after other quiet activities — an outcome providing proof of principle that mindfulness practice can lead to epigenetic alterations of the genome.

Previous studies in rodents and in people have shown dynamic epigenetic responses to physical stimuli such as stress, diet, or exercise within just a few hours.

“Our genes are quite dynamic in their expression and these results suggest that the calmness of our mind can actually have a potential influence on their expression,” Davidson says.

“The regulation of HDACs and inflammatory pathways may represent some of the mechanisms underlying the therapeutic potential of mindfulness-based interventions,” Kaliman says. “Our findings set the foundation for future studies to further assess meditation strategies for the treatment of chronic inflammatory conditions.”

Study funding came from National Center for Complementary and Alternative Medicine (grant number P01-AT004952) and grants from the Fetzer Institute, the John Templeton Foundation, and an anonymous donor to Davidson. The study was conducted at the Center for Investigating Healthy Minds at the UW-Madison Waisman Center.

Journal Reference:

Perla Kaliman, María Jesús Álvarez-López, Marta Cosín-Tomás, Melissa A. Rosenkranz, Antoine Lutz, Richard J. Davidson. Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators.Psychoneuroendocrinology, 2014; 40: 96 DOI: 10.1016/j.psyneuen.2013.11.004

Opportunities 4 mindfulness

16 Wednesday Sep 2020

Posted by in grounding, Handout, Meditation, mindfulness, Wellness

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For most of us, a typical day begins when we get out of bed, wash, and then start our activities. At some point, we get a bite to eat, walk somewhere, and talk to someone. Often, by the end of the day we find ourselves stressed out and physically exhausted. It doesn’t have to be that way!

Everyday activities can be an opportunity for a meditation moments; bringing mindfulness, clarity, and peace into your day while energizing yourself and reducing stress.4_lies

A study published in the journal Consciousness and Cognition found: “Brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning.”

These brief mindfulness meditations can be done anywhere or anytime …well using common sense. Just like you should not text and drive I would not meditate and drive either.

Here are two examples of how to add meditation without taking time out of your schedule.

  1. When you get up in the morning, you usually wash. Let’s use washing your face for our first meditation opportunity. Feel the temperature of the water on your hands. Focus on the temperature as you add a little soap. Notice how the suds feel on your hand. When a thought comes in, think of it as someone else’s phone ringing. You hear it, but you don’t have to answer it. Next, feel your soapy hands or the washcloth on your face. Focus on that sensation as you wash your face. Next, feel the rinse water on your face — how does it feel? Is it too cold? Too hot? Just right? If your mind wanders, there is no need to judge, just go back to focusing on the feeling of the water on your face. As you towel off, feel the sensation of the air on your face. It’s that simple, you just meditated.
  2. As you go about your day, you are most likely waiting in line or in traffic, so take a moment to breathe. Everyone has to breathe, and there is no way the person in front of you in the coffee line will know you are meditating! Sense the breath coming in and out of your nose or mouth. Don’t worry about thoughts; you know what to do, think of your thoughts as someone else’s cellphone ringing. Some people like to label their thoughts as “thought” and then let them go. The important thing is returning to sensing your breath coming in and out of your body. You will feel your shoulders relax and your patience returning.