
big enough that it’s worth answering but little enough that you can actually answer
11 Thursday Jan 2024
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01 Wednesday Nov 2023
Posted in brain
≈ Comments Off on Self-Control Can Be Draining
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The human body has a finite number of resources, and scientists are always discovering more about how these resources are shared, depleted, and replenished. Now a new study suggests that the areas in your brain responsible for self-control and forming memories are closely linked – in other words, if you’re concentrating hard on staying disciplined, you’re probably becoming less adept at remembering what’s happening.

Researchers Yu-Chin Chiu and Tobias Egner from Duke University in the US asked a group of volunteers to recognize a series of faces, both with and without the inclusion of a self-control test in the middle. They found that having to exercise self-control had a negative impact on the participants’ ability to recall which pictures they’d previously seen. The same experiment was then repeated with a new set of volunteers and brain-scanning fMRI (functional magnetic resonance imaging) equipment on hand.
The pair discovered that one area of the brain – the ventrolateral prefrontal cortex – was activated frequently during the self-control test and predicted the strength of the volunteers’ memory later on. The findings suggest that self-control and memory compete for the same resources inside the brain and support the theory that inhibiting ourselves can also cause us to forget more easily.
“The control demands of response inhibition divert attention away from stimulus encoding, thereby weakening memory traces for inhibitory cues,” the researchers conclude in The Journal of Neurosience. “These findings shed new light on the relation between the control process of response inhibition and the cognitive domains of perception, attention, and memory.”
The self-control test used was a traditional Go/No-Go task: these tasks work by asking participants to view a series of items and push a button only when certain criteria are met – in the case of this experiment, when the face shown is male rather than female. The theory is that those who are able to hold back from a button push when necessary are those with the strongest self-control (or “response inhibition”, as neuroscientists like to call it). The participants were not told in advance that they would need to remember the faces they were shown.
“The scans revealed that responding to a cue and inhibiting a response produced overlapping activation patterns in brain regions within the right frontal and parietal lobes, a network that has previously been implicated in response inhibition,” Mo Costrandi reports for The Guardian. “Crucially, ‘no-go’ trials produced greater activation of this network than ‘Go’ trials, and activity in one specific brain region (the ventrolateral prefrontal cortex) predicted the strength of the participants’ memory, such that the greater the observed network activation, the more likely the participants were to forget that face later on.”
The researchers admit their theory is still “speculative” for now, but if further study confirms the link, they believe their discovery could be used to treat people who have problems with self-control: those suffering from ADHD (Attention Deficit Hyperactivity Disorder), for example, or some form of addiction.
One scenario put forward by the pair is having to suddenly cancel a lane change on the motorway because a car is already in the spot you want to move into. If they’re right, the act of having to control and inhibit your actions would make it less likely that you would remember the details of the incident – such as the make and model of the car that was blocking your path.
18 Wednesday Oct 2023
Posted in Addiction
≈ Comments Off on Neuroscience, Addiction, Theory
Over the years I have read articles and case files of clients that suggest there is an abundance of anxiety and anxiety related disorders with people who experience alcohol and drug addiction. One of the chief components that produce anxiety is stress and according to Volkow and Li (2005) stress increases vulnerability to drug use and relapse in those addicted. They both argue that there is evidence that, “corticotropin-releasing factor (CRF) might play a linking role through its effects on the mesocorticolimbic dopamine system and the hypothalamic-pituitary–adrenal axis15-16” (Volkow, Li, 2005, p 1429). In simpler terms, stress produces CRF which affects the limbic system and the adrenals which in turn increases the stress response cycle.
In thinking about stress I stumbled across another article in the same issue of Nature and Neuroscience that talked about stress like responses, abet in a somewhat indirect manner. The article, by Antoine Bechara (2005) talks about the amygdala being out of balance. Bechara argues that addicted people become unable to make drug-use choices on the basis of long-term outcome because of hyperactivity within the amygdala (Bechara, 2005, p.1458). The amygdala which signals pain or pleasure of immediate prospects, overpowers the reflective prefrontal cortex system for signaling pain or pleasure of future prospects thus altering the decision making process. Bachara goes on to say that substance use can trigger involuntary signals originating from the amygdala that modulate, bias or even hijack the goal-driven cognitive resources that are needed for the normal operation of the reflective system and for exercising the willpower to resist drugs (Bechara, 2005, p.1458).
Knowing the basics that there is a relationship between the amygdala, drug use and stress I am willing to hypothesize that there is a circular connection here. Stress (and drug use) changes the composition of the chemicals that move through the body, this changed composition changes us more by altering the functions in the amygdala, which leads to changes in the decision making process. This combination of factors (stress-chemical composition-amygdala- and temperament) could be an over whelming force.
In fact, as long as I am going out on a limb and possibly completely limbless, I hypothesize that this stress amygdala cycle maybe related to the high/low reactive response Kagan noticed behaviorally in infants some thirty plus years ago at Harvard.

From Kagan’s perspective, temperament is an emotional/behavioral bias, independent of cognitive abilities, that affects receptivity to certain moods and emotions (Mitchell, 2006). Temperament has an effect on the neural chemistry of the brain and thus the sensitivity of certain receptors. Kagan theorized this is based on inherited factors that control the amygdala and thus the production of chemicals in the brain (Mitchell, 2006). This sensitivity, Kagan believes, is the basis of the behavioral/temperamental aspect of an individual.
In Kagan’s theory the chemical production of the amygdala alters receptor connections forming what he describes as high and low reactive (Mitchell, 2006). A high reactive is a high level of arousal to stimuli (crying), versus a low reactive which has a more relaxed reaction to stimuli. Highs have a more active amygdala, and tend to need to be in more control (control their responses and avoid the high reactive reactions).
Thus Bechara theory that drugs stimulate the amygdala maybe the same responses/reactions that Kagan saw in high reactive individuals. If one is a high reactive addict and you are surrounded by stimuli your inherent reaction is to want to control your high response because it creates tension within. The addict wants to quiet the tension, and the brain remembers that using fills that immediate need for control by quieting the reactions. But the drug use only temporally gives control as it also creates a hyperactive response in the amygdala which also reinforces that experience/feeling/thought that it’s more important to use now and not worry about later.
This hypothetical situation might manifest itself somatically by the addict contracting in response to memories of the original or current stressor stimuli for example. This contraction may have become neurologically and psychologically habituated as, “the body movements we develop when we are young are the modus operandi of dissociating” (Caldwell, 1996, p. 28). This contraction would possibly be followed by the person moving to remedy the situation by desensitization through a known movement pattern of perhaps contraction and release. This contraction/release could be a strain/release pattern, followed by a stop/go hesitation pattern as the person struggles with the need to control/quiet the self and the amygdala sends signals/memories of use that overrule the reflective prefrontal cortex. The person uses and goes into a running/drifting rhythm followed by even flow as the effects of the usage wears off.
Despite some 40 plus years of working with folks using movement and therapy I am still learning about movement and its relationship to addictions and disorders (disharmony) in general. I feel like I am also in the beginning stages of learning about neuroscience and the body with its behaviors. I get a wee bit excited when I think about the journals and articles that I have had only a chance to skim or read once and the connections with addictions as well as Kagan, Bachara, Volkow, Li, and others theories of addiction and personality. I never would have thought I would spend so much time looking at addictions but I see in adults with addictions many issues; adolescence, child hood trauma, dysfunctional families, depression, anxiety, low self esteem, disassociation from the body and from feelings. One population with many pathologies, just like every other population (humans) I suppose.
References
AHD, American Heritage Dictionary of the English Language, Fourth Edition. (2000) Houghton Mifflin Company. Retrieved February 28 2008 from Yahoo Education and Reference Dictionary at http://education.yahoo.com/reference/dictionary/entry/addiction
Ballas,C. MD. (2008). Medical Encyclopedia: Addiction. Retrieved February 27 2008 from National Institutes of Health at http://www.nlm.nih.gov/medlineplus/ency/article/001522.htm
Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nature Neuroscience. Vol 8, no. 11 Novemenber 2005.
Cadlwell, C. (1996). Getting our bodies back. Boston: Shambahala.
Capello, P,P. (2008). Dance/Movement Therapy with Children Throughout the World. American Journal Dance Therapy. (2008) Vol. 30. pg: 24–36
Fisher, B. MA, DTR. (1990). Dance/Movement Therapy:Its use in a 28 day substance abuse program. The Arts in Psychotherapy. Vol 17, pp.325-331
Fraser, J. S., & Solovey, A. D. (2007). Substance Abuse and Dependency. Second-order change in psychotherapy: The golden thread that unifies effective treatments., 223-244.
Lewis, P. (2003) Marian Chace Foundation Annual Lecture: Dancing with the Movement of the River. American Journal of Dance Therapy Vol. 25, No. 1, Spring/Summer 2003
Milliken, R. (1990). Dance/movement therapy with the substance abuser. The Arts in Psychotherapy, The creative arts therapies in the treatment of substance abuse, 17(4), 309-317.
Mitchell, N. (2006, August 26). All in the mind: Jerome Kagan, the father of temperament. Australia Broadcast Corporation, Radio National. Retrieved August 26, 2006, from http://abc.net.au/rn/aim/
TIPS, National Library of Medicine. (2008). Groups and substance abuse treatment: From Treatment Improvement Protocol Series. Retrieved February 25 2008 from Health Services Technology/Assessment Texts http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat5.section.78466
NIDA, National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA). (2008). NIDA Info-Facts: Nationwide Trends. Retrieved February 22 2008 from U.S. Department of Health and Human Services. http://www.nida.nih.gov/Infofacts/nationtrends.html
Volkow,N. Li, Ting-Kai. (2005). The neuroscience of addiction. Nature Neuroscience. Vol 8, no. 11 Novemenber 2005 .
Rose,S. (1995). Movement as metaphor in treating chemical addiction. In F.J. Levy (Ed.), Dance and other expressive art therapies. New York: Routledge.
27 Wednesday Sep 2023
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You’ve probably heard of the brain’s reward network. It’s activated by basic needs — including food, water and sex — and releases a surge of the feel-good neurotransmitter dopamine when those needs are met. But it can also be hijacked by drugs, which lead to a greater dopamine release than those basic needs.
But the reward network isn’t the only brain network altered by drug use. A new review concluded that drug addiction affects six main brain networks: the reward, habit, salience, executive, memory and self-directed networks.
In 2016, a total of 20.1 million people ages 12 and older in the U.S. had a substance-use disorder, according to the National Survey on Drug Use and Health, an annual survey on drug use. And drug addiction, regardless of the substance used, had surprisingly similar effects on the addicted brain, said the review, published in the journal Neuron.

The review looked at more than 100 studies and review papers on drug addiction, all of which studied a type of brain scan called functional magnetic resonance imaging (fMRI).
More than half of the studies out there look at the effects of drug use on the reward network, said Anna Zilverstand, lead author of the new review and an assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai in New York City.
“Because we showed that the effects are very distributed across the six different networks … [we can conclude that] an approach that only looks at one of these networks isn’t really justified,” Zilverstand told Live Science. “This [finding] will hopefully lead other researchers to look beyond the reward network.”
For example, the memory network is pretty much ignored in research on substance-use disorders, Zilverstand said. This network allows humans to learn non-habit-based things, such as a new physics concept or a history lesson. Some research has suggested that in people with substance-use disorders, stress shifts the person’s learning and memory away from the memory network to the habit network, which drives automatic behavior, such as seeking and taking drugs.
Another less-studied network is the self-directed network, which is involved in self-awareness and self-reflection, the review said. In people with addictions, this network has been associated with increasing craving.
Two other networks are involved in substance-use disorders: The executive network is normally responsible for goal-maintaining and execution, but drugs can alter this network as well, reducing a person’s ability to inhibit their actions. The salience network picks up important cues in a person’s environment and redirects the individual’s attention to them. (In people with drug addiction, attention is redirected toward drugs, increasing craving and drug-seeking.)
Which comes first, the brain activity or the drug use?
“For me, the most surprising [finding] was how consistent the effects were across addictions,” Zilverstand said. What’s more, “the fact that the effects are quite independent of the specific drug use points to them being something general that might actually precede drug use rather than be a consequence of drug use.”
Zilverstand said she hopes that more studies will look at whether some people have abnormal brain activity in these six networks naturally and if that activity just gets exacerbated if they begin drug use. It’s important to know if some of these traits precede drug use; if that’s the case, it might be possible to identify people who are prone to addiction and intervene before an addiction begins, she said.

Some research has pointed toward this possibility already. For example, studies have shown that some people have “difficulties … inhibiting impulsiveness before drug use,” Zilverstand said. “Some of these impairments precede drug use, and they may become worse with more drug use, but they exist before the problem escalates.”
The good news, however, is that activity in four of these networks — executive, reward, memory and salience — moves back toward “normal” once drug use ends. “We know that four of the networks (partially — not fully) recover but not yet what happens to the other two networks,” Zilverstand said in an email.
Zilverstand added that she’s particularly excited about an ongoing study called the Adolescent Brain Cognitive Development (ABCD) Study, which is tracking 10,000 children across the U.S. from around ages 9 or 10 to age 20 (the children are now around 13). Some of these individuals will inevitably become addicted to drugs, most likely marijuana or alcohol, Zilverstand said.
“We’ll be able to see if the effects that we found [in the review] exist in youth who have not yet abused drugs,” she said, and she predicted that researchers will be able to find a lot of the effects identified in the review in the six brain networks.
The authors noted that because some regions of the brain are very small — for example, the amygdala, which is found toward the center of the brain — the studies can’t identify strong signals from those areas on brain scans. So, it’s possible that drugs affect additional networks in the brain that are hidden because of the limitations of our technologies, Zilverstand said.
“We don’t want to conclude that [those effects] don’t exist,” she said.
31 Wednesday May 2023
Posted in Coping Skills, Wellness
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Today more and more adults practice yoga, and not surprisingly, there is research supporting its physical benefits. Studies show the practice—which combines stretching and other exercises with deep breathing and meditation—can improve overall physical fitness, strength, flexibility and lung capacity, while reducing heart rate, blood pressure and back pain.
But what is perhaps unknown to those who consider yoga just another exercise form is that there is a growing body of research documenting yoga’s psychological benefits. Several recent studies suggest that yoga may help strengthen social attachments, reduce stress and relieve anxiety, depression and insomnia. Researchers are also starting to claim some success in using yoga and yoga-based treatments to help active-duty military and veterans with post-traumatic stress disorder.
“The evidence is showing that yoga really helps change people at every level,” says Stanford University health psychologist and yoga instructor Kelly McGonigal, PhD.
That’s why more clinicians have embraced yoga as a complement to psychotherapy, McGonigal says. They’re encouraging yoga as a tool clients can use outside the therapy office to cope with stress and anxieties, and even heal emotional wounds.
“Talk therapy can be helpful in finding problem-solving strategies and understanding your own strengths and what’s happening to you, but there are times when you just need to kind of get moving and work through the body,” says Melanie Greenberg, PhD, a psychology professor at Alliant International University, who has studied yoga’s benefits to mental health.

The mind-body meld
According to a study by Sherry A. Glied, PhD, professor of health policy and management at Columbia University, and Richard G. Frank, PhD, professor of health-care policy at Harvard Medical School, published in the May/June Health Affairs (Vol. 28, No. 3), the rate of diagnosed cases of mental disorders increased dramatically between 1996 and 2006—doubling among adults age 65 and older, and rising by about 60 percent among adults 18 to 64. During that same time period, rates of psychotropic medication use rose by about the same percentages among these groups.
In light of these numbers, yoga remains a natural and readily available approach to maintaining wellness and treating mental health issues, says Sat Bir Khalsa, PhD, a neuroscientist and professor of medicine at Harvard Medical School at Brigham and Women’s Hospital in Boston who studies yoga’s effects on depression and insomnia. Khalsa, who has practiced yoga for more than 35 years, says several studies in his 2004 comprehensive review of yoga’s use as a therapeutic intervention, published in the Indian Journal of Physiology and Pharmacology (Vol. 48, No. 3), show that yoga targets unmanaged stress, a main component of chronic disorders such as anxiety, depression, obesity, diabetes and insomnia. It does this, he says, by reducing the stress response, which includes the activity of the sympathetic nervous system and the levels of the stress hormone cortisol. The practice enhances resilience and improves mind-body awareness, which can help people adjust their behaviors based on the feelings they’re experiencing in their bodies, according to Khalsa.
While scientists don’t have quite the full picture on how yoga does all that, new research is beginning to shed light on how the practice may influence the brain. In a 2007 study in the Journal of Alternative and Complementary Medicine (Vol. 13, No. 4), researchers at Boston University School of Medicine and McLean Hospital used magnetic resonance imaging to compare levels of the neurotransmitter gamma-aminobutyric acid (GABA) before and after two types of activities: an hour of yoga and an hour of reading a book. The yoga group showed a 27 percent increase in GABA levels, which evidence suggests may counteract anxiety and other psychiatric disorders. GABA levels of the reading group remained unchanged.
“I believe if everyone practiced the techniques of yoga, we would have a preventive aid to a lot of our problems,” Khalsa says. “There would likely be less obesity and Type-II diabetes, and people would be less aggressive, more content and more integrated.”
Khalsa’s claims are backed by evidence supporting the social benefits of participating in a yoga class, says Stanford’s McGonigal. A series of experiments conducted by organizational behavior researchers at Stanford University and published in January’s Psychological Science (Vol. 20, No. 1) suggest that acting in synchrony with others—be it while walking, singing or dancing—can increase cooperation and collectivism among group members.
“In a yoga class, everyone is moving and breathing in at the same time and I think that’s one of the undervalued mechanisms that yoga can really help with: giving people that sense of belonging, of being part of something bigger,” McGonigal says.
Psychologists are also examining the use of yoga with survivors of trauma and finding it may even be more effective than some psychotherapy techniques. In a pilot study at the Trauma Center at the Justice Resource Institute in Brookline, Mass., women with PTSD who took part in eight sessions of a 75-minute Hatha yoga class experienced significantly reduced PTSD symptoms compared with those participating in a dialectical behavior therapy group. The center recently received a grant from the National Center for Complementary and Alternative Medicine to conduct a randomized, single-blind, controlled study to further examine whether, as compared with a 10-week health class, yoga improves the frequency and severity of PTSD symptoms and other somatic complaints as well as social and occupational impairments among female trauma survivors.
“When people experience trauma, they may experience not only a sense of emotional disregulation, but also a feeling of being physically immobilized,” says Ritu Sharma, PhD, project coordinator of the center’s yoga program, who only began practicing yoga when she started leading the program. “Body-oriented techniques such as yoga help them increase awareness of sensations in the body, stay more focused on the present moment and hopefully empower them to take effective actions.”
And in what is becoming one of the most widely applied yoga-based trauma treatments, clinical psychologist Richard Miller, PhD, has developed a nine-week, twice-weekly integrative restoration program based on the ancient practice of yoga Nidra. In 2006, the Department of Defense began testing iRest with active-duty soldiers returning from Iraq and Afghanistan who were experiencing PTSD. At the end of the program, participants reported a reduction in insomnia, depression, anxiety and fear, improved interpersonal relations and an increased sense of control over their lives. Since then, iRest classes have been established at VA facilities in Miami, Chicago and Washington, D.C. Miller has also helped develop similar programs for veterans, homeless people and those with chemical dependencies and chronic pain.
“The program teaches them skills they can integrate into their daily lives, so that in the midst of a difficult circumstance, they have the tools to be able to work in the moment,” says Miller, president of the Integrative Restoration Institute in San Rafael, Calif.
New research is also supporting yoga’s benefit for other mental illnesses. An as-yet-unpublished randomized control trial by Khalsa offers insight into how yoga may reduce insomnia. In this study, 20 participants who practiced a daily 45-minute series of Kundalini yoga techniques shortly before bedtime for eight weeks reported significant reductions in insomnia severity as compared with those told to follow six behavioral recommendations for sleep hygiene. And a 2007 study supports yoga’s potential as a complementary treatment for depressed patients taking antidepressant medication but only in partial remission. University of California, Los Angeles, psychologist David Shapiro, PhD, found that participants who practiced Iyengar yoga three times a week for eight weeks reported significant reductions in depression, anxiety and neurotic symptoms, as well as mood improvements at the end of each class (Evidence-based Complementary and Alternative Medicine, Vol. 4, No. 4). Many of the participants achieved remission and also showed physiological changes, such as heart rate variability, indicative of a greater capacity for emotional regulation, Shapiro says.
Putting yoga into practice
While she cautions against teaching yoga to clients without formal training, McGonigal and others say psychologists can use psychotherapy sessions to practice yoga’s mind-body awareness and breathing techniques. Simple strategies—such as encouraging clients to get as comfortable as possible during their sessions or to pay attention to how their body feels when they inhale and exhale—teach clients to be in the here and now.
“These by themselves would be considered yoga interventions because they direct attention to the breath and help unhook people from thoughts, emotions and impulses that are negative or destructive,” she says.
Alliant International University psychology professor Richard Gevirtz, PhD, agrees that alternatives to traditional psychotherapy may help clinicians make progress with difficult clients.
“Psychologists have painted themselves in the corner by only doing talk therapy,” Gevirtz says. “There’s much more that can be accomplished if you integrate it with other sorts of modalities, such as biofeedback, relaxation training or yoga.”
In fact, some psychologists say yoga may not really be so special when it comes to improving one’s mental state, and that several forms of exercise may provide mood-enhancing benefits.
In a 2007 study by researchers at Bowling Green State University, 36 participants kept mood diaries during the first and final four weeks of a 16-week weight-loss program. On the days participants engaged in planned exercise—typically walking for 30 to 60 minutes—they reported a better mood at night as compared to in the morning, before exercising (Journal of Sport & Exercise Psychology, Vol. 29, No. 6).
“It seems that many types of exercise—particularly non-competitive exercise—are related to positive mood alteration,” says Bonnie Berger, EdD, one of the study’s co-authors and professor and director of Bowling Green’s School of Human Movement, Sport and Leisure Studies.
Psychologists may also benefit from using yoga and other forms of exercise for their own care, Greenberg says. In a 2007 survey of licensed APA members by the APA Board of Professional Affairs Advisory Committee on Colleague Assistance, 48 percent reported that vicarious trauma and compassion fatigue are likely to affect their functioning.
“Practicing yoga personally and adopting a stance based on yoga principles such as non-judgment, compassion, spirituality and the connection of all living things can help relieve stress, enhance compassion and potentially make you a better therapist,” she says. “If you can come to a level of peace with yourself, there may be more nurturing that you exude toward your patients.”
12 Wednesday Apr 2023
Posted in brain, Depression
≈ Comments Off on Researchers pinpoint brain’s happiness region
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Happiness is the meaning and the purpose of life, the whole aim and end of human existence,” the ancient Greek philosopher Aristotle once said. But how does one reach this goal? According to a new study by researchers from Japan, a person’s happiness may depend on the size of a specific brain region.
Researchers found people who were happier had larger gray matter volume in the precuneus region of the brain.
Study leader Dr. Wataru Sato, of Kyoto University in Japan, and colleagues publish their findings in the journal Scientific Reports.
The definition of happiness has been debated for centuries. In recent years, psychologists have suggested that happiness is a combination of life satisfaction and the experience of more positive than negative emotions – collectively deemed “subjective well-being.”

But according to Dr. Sato and his colleagues, the neurological mechanisms behind a person’s happiness were unclear.
“To date, no structural magnetic resonance imaging (MRI) investigation of the construct has been conducted,” they note.
“Identification of the neural substrates underlying subjective happiness may provide a complementary objective measure for this subjective construct and insight into its information-processing mechanism.”
Meditation may boost happiness by targeting precuneus brain region
To address this research gap, the team used MRI to scan the brains of 51 study participants.
After the scans, subjects were asked to complete three short questionnaires that asked them how satisfied they are with their lives, how happy they are and how intensely they feel positive and negative emotions.
The researchers found that individuals who had higher happiness scores had larger gray matter volume in the precuneus of the brain – a region in the medial parietal lobe that plays a role in self-reflection and certain aspects of consciousness – than their unhappy counterparts.
What is more, the researchers found that one’s happiness may be driven by a combination of greater life satisfaction and intensity of positive emotion – supporting the theory of subjective well-being.
“These results indicate that the widely accepted psychological model postulating emotional and cognitive components of subjective happiness may be applicable at the level of neural structure,” they add.
These findings, the researchers say, indicate that individuals may be able to boost their happiness through practices that target the precuneus, such as meditation:
“Previous structural neuroimaging studies have shown that training in psychological activities, such as meditation, changed the structure of the precuneus gray matter.
Together with these findings, our results suggest that psychological training that effectively increases gray matter volume in the precuneus may enhance subjective happiness.”

Dr. Sato adds that, while further research is required, these current findings may be useful for developing psychological programs that boost a person’s happiness
01 Wednesday Feb 2023
Posted in brain
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A team of neuroscientists at the University of Toronto in Canada has discovered a reason why we often struggle to remember small details of past experiences.
Many events in our lives resemble experiences we have had before, without being identical to them.
Whenever you attend a party, for example, you may well take along a gift, such as a bottle of wine or a box of chocolates, but the gift will differ on each occasion.
Researchers believe that as our memories for such events become older, the incidental details unique to each event (such as the identity of the gift) are mostly forgotten.

However, the common underlying patterns (what parties are like in general) are retained. This allows us to accumulate knowledge to guide our behavior in similar situations in the future.
Studies in rodents and people have shown that a region of the brain called the medial prefrontal cortex (mPFC) stores long-term memories about experiences.
But to what extent do neurons in this region represent abstract generalized knowledge as opposed to the specific incidental details?
“Memories of recent experiences are rich in incidental detail but, with time, the brain is thought to extract important information that is common across various past experiences,” said Dr. Kaori Takehara-Nishiuchi, senior author of the study.
“We predicted that groups of neurons in the mPFC build representations of this information over the period when long-term memory consolidation is known to take place, and that this information has a larger representation in the brain than the smaller details.”
To test their prediction, Dr. Takehara-Nishiuchi and her colleagues studied how two different memories with overlapping associative features are coded by neuron groups in the mPFC of rat brains, and how these codes change over time.
Rats were given two experiences with an interval between each: one involving a light and tone stimulus, and the other involving a physical stimulus. This gave them two memories that shared a common stimulus relationship.
The researchers then tracked the neuron activity in the animals’ brains from the first day of learning to four weeks following their experiences.
“This experiment revealed that groups of neurons in the mPFC initially encode both the unique and shared features of the stimuli in a similar way,” said Mark Morrissey, first author on the study.
“However, over the course of a month, the coding becomes more sensitive to the shared features and less sensitive to the unique features, which become lost.”
Further experiments also revealed that the brain can adapt the general knowledge gained from multiple experiences immediately to a new situation.
“This goes some way to answering the long-standing question of whether the formation of generalized memory is simply a result of the brain’s network ‘forgetting’ incidental features,” Morrissey said.
“On the contrary, we show that groups of neurons develop coding to store shared information from different experiences while, seemingly independently, losing selectivity for irrelevant details.”
“The unique coding property of the mPFC identified in the study may support its role in the formation, maintenance, and updating of associative knowledge structures that help support flexible and adaptive behavior in rats and other animals,” he said.
30 Friday Dec 2022
Posted in brain
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07 Wednesday Dec 2022
Posted in brain, Depression
≈ Comments Off on Brain Scan May Help Decide Treatment for Depression
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New research from Emory University in Atlanta has found that specific patterns of activity on brain scans may help clinicians identify whether psychotherapy or antidepressant medication is more likely to help individual patients recover from depression.
The study, called PReDICT, randomly assigned patients to 12 weeks of treatment with one of two antidepressant medications or with cognitive behavioral therapy (CBT).
At the start of the study, patients underwent a functional MRI brain scan, which was then analyzed to see whether the outcome from CBT or medication depended on the state of the brain prior to starting treatment.

The MRI scans identified that the degree of functional connectivity between an important emotion processing center — the subcallosal cingulate cortex — and three other areas of the brain was associated with the treatment outcomes, according to the researchers.
Specifically, patients with positive connectivity between the brain regions were significantly more likely to achieve remission with CBT, while patients with negative or absent connectivity were more likely to benefit from antidepressant medication.
“All depressions are not equal and like different types of cancer, different types of depression will require specific treatments. Using these scans, we may be able to match a patient to the treatment that is most likely to help them, while avoiding treatments unlikely to provide benefit,” said Helen Mayberg, M.D., a professor of psychiatry, neurology and radiology at Emory University School of Medicine.
Mayberg and her co-investigators, Boadie Dunlop, M.D., director of the Emory Mood and Anxiety Disorders Program, and W. Edward Craighead, Ph.D., a professor of psychiatry and behavioral sciences, sought to develop methods for a more personalized approach to treating depression.
Current treatment guidelines for major depression recommend that a patient’s preference for psychotherapy or medication be considered in selecting the initial treatment approach. However, in the PReDICT study, patients’ preferences were only weakly associated with outcomes — preferences predicted treatment drop-out, but not improvement, the study found.
These results are consistent with prior studies, suggesting that achieving personalized treatment for depressed patients will depend more on identifying specific biological characteristics in patients rather than relying on their symptoms or treatment preferences, the researchers noted.
The results from PReDICT suggest that brain scans may offer the best approach for personalizing treatment going forward, they add.

The researchers recruited 344 patients for the study from across the metro Atlanta area. Researchers note they were able to convene a more diverse group of patients than other previous studies, with roughly half of the participants self-identified as African American or Hispanic.
“Our diverse sample demonstrated that the evidence-based psychotherapy and medication treatments recommended as first-line treatments for depression can be extended with confidence beyond a white, non-Hispanic population,” said Dunlop.
“Ultimately our studies show that clinical characteristics, such as age, gender, etc., and even patients’ preferences regarding treatment, are not as good at identifying likely treatment outcomes as the brain measurement,” concluded Mayberg.
The study results were published in the American Journal of Psychiatry.
09 Wednesday Nov 2022
Posted in brain
≈ Comments Off on Arts appear to play role in brain development
Brain research in the past several years is just beginning to uncover some startling ideas about how students learn. First came the proof, some years ago, that our brains do not lose brain cells as we get older, but are always capable of growing.
Now neuroscientists are investigating how training students in the arts may change the structure of their brains and the way they think. They are asking: Does putting a violin in the hands of an elementary school student help him to do math better? Will learning to dance or paint improve a child’s spacial ability or ability to learn to read?
Research in those areas, Harvard professor Jerome Kagan said, is “as deserving of a clinical trial as a drug for cancer that has not yet been shown to be effective.”

There aren’t many conclusions yet that can be translated into the classroom, but there is an emerging interdisciplinary field between education and neuroscience. Like Hopkins, Harvard also has created a center to study learning and the brain.
Much of the research into the arts has centered on music and the brain. One researcher studying students who go to an arts high school found a correlation between those who were trained in music and their ability to do geometry. Yet another four-year study, being conducted by Ellen Winner of Boston College and Gottfried Schlaug of Harvard, is looking at the effects playing the piano or the violin has on students who are in elementary school.
Winner said she was quite skeptical of claims that schools that had introduced the arts had seen an increase in test scores and a generally better school climate. She had previously looked at those claims and found they couldn’t be backed up by research.
However, she is in the midst of a four-year study of elementary students that has shown some effects: One group is learning an instrument, and another is not. “It is the first study to demonstrate brain plasticity in young children related to music playing,” Schlaug said.
The study Winner is working on has shown that children who receive a small amount of training — as little as half an hour of lessons a week and 10 minutes of practice a day — do have structural changes in their brains that can be measured. And those students, Winner said, were better at tests that required them to use their fingers with dexterity.
About 15 months after the study began, students who played the instrument were not better at math or reading, although the researchers are questioning whether they have assessments that are sensitive enough to measure the changes. They will continue the study for several more years.
Charles Limb, a Johns Hopkins doctor and a jazz musician, studied jazz musicians by using imaging technology to take pictures of their brains as they improvised. He found that they allowed their creativity to flow by shutting down areas that regulated inhibition and self-control. So are the most creative people able to shut down those areas of the brain?
Most of the new research is focusing on the networks of the brain that are involved in specific tasks, said Michael Posner, a researcher at the University of Oregon. Posner has studied the effects of music on attention. What he found, he said, was that in those students who showed motivation and creativity, training in the arts helped develop their attention and their intelligence. The next great focus in this area, he said, is on proving the connection that most scientists believe exists between the study of music and math ability.
The imaging is now so advanced that scientists can already see the difference in the brain networks of those who study a string instrument and those who study the piano intensely.
The brain research, while moving quickly by some measures, is still painfully slow for educators who would like answers today. Morgan, the Washington County schools chief, said some research did help her support the drive to build the Barbara Ingram School for the Arts in Hagerstown.
Mariale Hardiman, the former principal of Roland Park Elementary/Middle School, was once one of those principals who focused a lot of attention on reading and math scores. But she saw what integrating the arts into classrooms could do for students, she said, and she then began her own research into the subject.
She is now the co-director of the Hopkins Neuro-Education Initiative. She said there are a myriad of questions that could be answered in the research that is just starting, but there are two she would like to see approached: Do children who learn academic content through the arts tend to hold onto that knowledge longer? And are schools squeezing creativity out of children by controlling so much of their school day?
Even without research though, Kagan of Harvard said there is ample evidence of the value of an arts education because so many children who aren’t good at academics can gain self-confidence through the arts.
“The argument for an arts education is based not on sentimentality but on pragmatism,” he said. “If an arts program only helped the 7 million children in the bottom quartile, the dropout rate would drop.”
05 Wednesday Oct 2022
Recent research from Brown University could pave the way for new methods of treatment for those recovering from addiction. Researchers identified an exact brain region in rats where the neural steps leading to drug relapse take place, allowing them to block a crucial step in the process that leads to stress-induced relapse.
Prior research has established that acute stress can lead to drug abuse in vulnerable individuals and increase the risk of relapse in recovering addicts. But the exact way that stress triggers the neural processes leading to relapse is still not clearly understood. The Brown study provides new insights on how stress triggers drug abuse and could lead to more effective treatments for addiction.
According to the study, stress has significant effects on plasticity of the synapses on dopamine neurons in the ventral tegmental area (VTA), the brain region where the neural activities leading to a stress-induced drug relapse take place.
Stress activates kappa opioid receptors (KORs) in the VTA, and the researchers found that by blocking the KORs, they could prevent the rats from relapsing to cocaine use while under stress.
Published in the journal Neuron, the study shows blocking these receptors may be a critical step in preventing stress-related drug relapses in humans, as well. The chemical used to block the receptor, “nor-BMI,” may eventually be tested on humans, according to the study’s authors.

“If we understand how kappa opioid receptor antagonists are interfering with the reinstatement of drug seeking, we can target that process,” senior study author Julie Kauer said in a statement. “We’re at the point of coming to understand the processes and possible therapeutic targets. Remarkably, this has worked.”
Kauer noted that the study builds upon over a decade of research on how changes in brain synapses relate to behaviors like addiction. The advance is significant and could accelerate progress towards a medication for those struggling to recover from addiction.
“If we can figure out how not only stress, but the whole system works, then we’ll potentially have a way to tune it down in a person who needs that,” Kauer said.
02 Friday Sep 2022
Posted in Research
≈ Comments Off on US-European Satellite Will Make World’s First Global Freshwater Survey
https://nasa.gov/feature/jpl/us-european-satellite-will-make-world-s-first-global-freshwater-survey
“A collaboration between NASA and the French space agency Centre National d’Études Spatial (CNES), with contributions from the Canadian Space Agency and the United Kingdom Space Agency, SWOT is scheduled to launch in November from Vandenberg Space Force Base in California.“
“SWOT has several key tasks, including measuring the height of water bodies on Earth’s surface. Over the ocean, the satellite will be able to “see” features like eddies less than 60 miles (100 kilometers) across – smaller than those that previous sea level satellites could observe. SWOT will also measure more than 95% of Earth’s lakes larger than 15 acres (6 hectares) and rivers wider than 330 feet (100 meters) across.”
via #NASA_APP
05 Friday Aug 2022
22 Friday Jul 2022
Posted in Pets
≈ Comments Off on What animals are thinking and feeling, and why it should matter | Carl Safina | TEDxMidAtlantic
01 Friday Apr 2022
Posted in dogs
≈ Comments Off on Researcher Explains Why Cats May Like Their Owners as Much as Dogs | WIRED
29 Wednesday Dec 2021
Posted in Depression, Mental Health, Research, Uncategorized
≈ Comments Off on Depression and the inflammatory process
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Most people feel down, tired and inactive when they’re injured or ill. This “sickness behavior” is caused by the activation of the body’s immune response. It’s the brain’s way of conserving energy so the body can heal.
This immune response can also occur in people with depression. This has prompted some researchers and clinicians to hypothesise that depression is actually a side effect of the inflammatory process.
But while there may be a connection between inflammation and depression, one doesn’t necessarily lead to the other. So it’s too simplistic to say depression is a physical, rather than a psychiatric, illness.
University of California clinical psychologist and researcher George Slavich is one of the key recent proponents of depression as a physical illness. He hypothesises that social threats and adversity trigger the production of pro-inflammatory “cytokines”. These are messenger molecules of the immune system that play a critical role in orchestrating the host’s response to injury and infection.
This inflammatory process, Slavich argues, can initiate profound behavioral changes, including the induction of depression.

The idea that the activation of the immune response may trigger depression in some people is by no means a new one. Early descriptions of post-influenza depression appeared in the 19th century in the writings of English physician Daniel Tuke.
But it was not until the 1988 seminal paper, published by veterinarian Benjamin Hart, that the phenomenon of acute “sickness behavior” caught the interest of the scientific community.
Hart described his detailed observations of the “behavior of sick animals”. During acute infection, and in response to fever, the animals sought sleep, lost their appetite, showed a reduction in activity, grooming and social interactions, as well as showing signs of “depression”.
Just like the immune response itself, these changes reflect an evolved survival strategy that shifts priorities toward energy conservation and recovery.
Cytokine-induced sickness behavior has subsequently been studied as an example of communication between the immune system and the brain.
The behavioral changes during sickness resemble those associated with depression, so it didn’t take long for researchers to make a connection between the phenomenon of sickness behavior and mental disorders.
Such speculation was strengthened by research showing that depressive states can be experimentally induced by administering cytokines and other immunogenic agents (such as vaccines) that cause an inflammatory response.
Depression is frequently associated with inflammatory illnesses such as heart disease and rheumatoid arthritis. It’s also a side effect of treatment with cytokines to enhance the immune system.
Over recent decades, researchers have made progress in understanding how inflammation may impact on the activity of signalling pathways to and from the brain, as well as on the functioning of key neural systems involved in mood regulation.
From the available evidence it’s clear, however, that not everyone who suffers from depression has evidence of inflammation. And not all people with high levels of inflammation develop depression.
Trajectories of depression depend on a complex interplay of a spectrum of additional risk and resilience factors, which may be present to varying degrees and in a different combination in any individual at different times. These factors include the person’s:
In line with the notion that inflammation drives depression, some researchers have already trialled the effectiveness of anti-inflammatory therapy as a treatment for depression.
While some recipients (such as those with high levels of inflammation) showed benefit from the treatment, others without increased inflammation did not. This supports the general hypothesis.
However, in our desire to find more effective treatments for depression, we should not forget that the immune response, including inflammation, has a specific purpose. It protects us from infection, disease and injury.
Cytokines act at many different levels, and often in subtle ways, to fulfill their numerous roles in the orchestration of the immune response. Undermining their vital role could have negative consequences.
The recent enthusiasm to embrace inflammation as the major culprit in psychiatric conditions ignores the reality that “depression” is not a single condition. Some depressive states, such as melancholia, are diseases; some are reactions to the environment; some are existential; and some normal.
Such separate states have differing contributions of biological, social and psychological causes. So any attempt to invoke a single all-explanatory “cause” should be rejected. Where living organisms are concerned it is almost never that simple.
In the end, we cannot escape the reality that changes must occur at the level of the brain, in regions responsible for mood regulation, for “depression” to be experienced.
15 Wednesday Dec 2021
Posted in Health and wellness, Research
≈ Comments Off on Narrative Medicine
From Wikipedia: Narrative medicine is a medical approach that utilizes people’s narratives in clinical practice, research, and education as a way to promote healing. It aims to address the relational and psychological dimensions that occur in tandem with physical illness, with an attempt to deal with the individual stories of patients. In doing this, narrative medicine aims not only to validate the experience of the patient, but also to encourage creativity and self-reflection in the physician.
Excerpt below from Philosophy, Ethics, and Humanities in Medicine: Exploring perception and usage of narrative medicine by physician specialty: a qualitative analysis.
Background
Narrative medicine is a well-recognized and respected approach to care. It is now found in medical school curricula and widely implemented in practice. However, there has been no analysis of the perception and usage of narrative medicine across different medical specialties and whether there may be unique recommendations for implementation based upon specialty. The aims of this study were to explore these gaps in research.
Fifteen senior physicians who specialize in internal medicine, pediatrics, or surgery (5 physicians from each specialty) were interviewed in a semi-structured format about the utilization, benefits, drawbacks (i.e., negative consequences), and roles pertaining to narrative medicine. Qualitative content analysis of each interview was then performed.
Excerpt from : Exploring perception and usage of narrative medicine by physician specialty: a qualitative analysis.
10 Friday Dec 2021
Posted in Research, Uncategorized
≈ Comments Off on Human Skin Color
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24 Wednesday Nov 2021
With more than 100 people dying from opioid overdoses each day in the U.S., new approaches to treating opioid-use disorders are needed. Emma Rose, assistant research professor with Penn State’s Edna Bennett Pierce Prevention Research Center, is leading a study that adds twice-weekly, mindfulness-based yoga to treatment plans for patients with opioid-use disorders in rural Pennsylvania.
“We hope to impart skills that help people to stay sober and stay in recovery for longer,” Rose said.
The study divides participants who are receiving medication-assisted treatment in three clinics in Lancaster, Pennsylvania, into two groups, with one group taking two one-hour online yoga classes twice per week for 8 weeks, while the control group will walk for exercise for up to 2 hours per week.
Mindful yoga can impact brain systems that play an important role in the success of addiction treatment — including our brains’ abilities to regulate craving, to adapt to new or changing events, and to ignore distractions, Rose explained.
Read the entire article HERE
13 Wednesday Oct 2021
Posted in creative arts therapy, Research, Therapy
≈ Comments Off on Preferences for group arts therapies
From BMJ Open:
Objectives The arts therapies include music therapy, dance movement therapy, art therapy and dramatherapy. Preferences for art forms may play an important role in engagement with treatment. This survey was an initial exploration of who is interested in group arts therapies, what they would choose and why.
Conclusions Large proportions of the participants expressed an interest in group arts therapies. This may justify the wide provision of arts therapies and the offer of more than one modality to interested patients. It also highlights key considerations for assessment of preferences in the arts therapies as part of shared decision-making.
Read the entire article at BMJ Open.
